Diclofenac dangers
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Diclofenac, marketedas Voltaren, Cataflam, Solaraze and Arthrotec, an older non-steroidal anti-inflammatory drug (NSAID), has been on the market for decades and is one of the most-widely prescribed anti-inflammatories in the world especially in Europe. At commonly prescribed doses, it was found to increase the risk of cardiovascular events primarily heart attack and sudden death by 40%. The good news from the study is that there are alternatives. “European consumers would be better off switching [from diclofenac] to naproxen,” says David Graham, a safety official at the US Food and Drug Administration, who authored an editorial1 accompanying the published review. Naproxen was found to neither increase nor decrease cardiac risk. The meta-analysis, published online today by the Journal of the American Medical Association, looked at 23 studies involving some 1.6 million people. The studies were not gold-standard clinical trials, but the review’s huge scope lends it weight, says Graham. “It looked at all NSAIDs across the board, at all available evidence for those NSAIDs. In that regard, it’s unprecedented and in my view becomes authoritative.” The study authors Patricia McGettigan of the University of Newcastle in New South Wales, Australia, and David Henry of Newcastle Mater Hospital in Waratah, New South Wales call for a review of the regulatory status of diclofenac, which is marketed as a generic drug and also under the trade names Voltaren, Cataflam, Solaraze and Arthrotec. For the future, researchers are aiming to find a class of anti-inflammatories that will both be kind to the stomach and to the heart. Research released by the Proceedings of the National Acadamy of Sciences this week shows promising news of a drug target, found in a mouse model, that slows the development of atherosclerosis. This might help a new class of ’super NSAIDs’ not only steer clear of heart disease risk but work to reduce it. Looking to make a change and lose some weight? I have reviewed the top diet on the internet and you can go and read over 200 comments people have made about why this diet has worked well for them, as well as some of the problems. Tags: American Medical Association, arthritis, atherosclerosis, Australia, David Graham, David Henry, Europe, heart attack, heart disease, New South Wales, Newcastle Mater Hospital, pain, Patricia McGettigan, safety official, the Journal of the American Medical Association, University of Newcastle in New South Wales, US Food and Drug Administration, vioxx, WaratahIf you like this post then you will probably like these other related items as well
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If you ever want to read a reader’s feedback
, I rate this article for four from five. Detailed info, but I have to go to that damn msn to find the missed parts. Thanks, anyway!